Cellular senescence of white blood cells in very long-term survivors after allogeneic hematopoietic stem cell transplantation: the role of chronic graft-versus-host disease and female donor sex
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- Gabriela M. Baerlocher
- Department of Hematology, University Hospital, Bern;
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- Alicia Rovó
- Department of Hematology, University Hospital, Basel; and
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- Astrid Müller
- Department of Clinical Research, University of Bern, Bern;
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- Sybille Matthey
- Department of Clinical Research, University of Bern, Bern;
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- Martin Stern
- Department of Hematology, University Hospital, Basel; and
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- Jörg Halter
- Department of Hematology, University Hospital, Basel; and
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- Dominik Heim
- Department of Hematology, University Hospital, Basel; and
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- Johannes Rischewski
- Department of Oncology, Children's University Hospital Basel, Basel, Switzerland
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- Alois Gratwohl
- Department of Hematology, University Hospital, Basel; and
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- André Tichelli
- Department of Hematology, University Hospital, Basel; and
抄録
<jats:title>Abstract</jats:title> <jats:p>In this single-center, cross-sectional study, we evaluated 44 very long-term survivors with a median follow-up of 17.5 years (range, 11-26 years) after hematopoietic stem cell transplantation. We assessed the telomere length difference in human leukocyte antigen-identical donor and recipient sibling pairs and searched for its relationship with clinical factors. The telomere length (in kb, mean ± SD) was significantly shorter in all recipient blood cells compared with their donors' blood cells (P < .01): granulocytes (6.5 ± 0.9 vs 7.1 ± 0.9), naive/memory T cells (5.7 ± 1.2 vs 6.6 ± 1.2; 5.2 ± 1.0 vs 5.7 ± 0.9), B cells (7.1 ± 1.1 vs 7.8 ± 1.1), and natural killer/natural killer T cells (4.8 ± 1.0 vs 5.6 ± 1.3). Chronic graft-versus-host disease (P < .04) and a female donor (P < .04) were associated with a greater difference in telomere length between donor and recipient. Critically short telomeres have been described in degenerative diseases and secondary malignancies. If this hypothesis can be confirmed, identification of recipients at risk for cellular senescence could become part of monitoring long-term survivors after hematopoietic stem cell transplantation.</jats:p>
収録刊行物
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- Blood
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Blood 114 (1), 219-222, 2009-07-02
American Society of Hematology