Oral mucositis: A challenging complication of radiotherapy, chemotherapy, and radiochemotherapy: Part 1, pathogenesis and prophylaxis of mucositis

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<jats:title>Abstract</jats:title><jats:sec><jats:title>Background.</jats:title><jats:p>Oral mucositis is a common sequel of radiotherapy, chemotherapy, and radiochemotherapy in patients with cancer or patients requiring hemopoietic stem cell transplants. Mucositis has a direct and significant impact on the duration of disease remission and cure rates, because it is a cancer treatment–limiting toxicity. Mucositis also affects survival because of the risk of infection and has a significant impact on the quality of life and cost of care.</jats:p></jats:sec><jats:sec><jats:title>Methods.</jats:title><jats:p>This article reviews publications on the etiopathogenesis and prevention of oral mucositis accessible from a MEDLINE search using as key words, mucositis, radiotherapy, chemotherapy, hemopoietic stem cell transplant, and oral.</jats:p></jats:sec><jats:sec><jats:title>Conclusions.</jats:title><jats:p>Of the current available products, ice chips and benzydamine have the strongest scientific evidence of support for prophylaxis of mucositis. © 2003 Wiley Periodicals, Inc. Head Neck 25: 000–000, 2003</jats:p></jats:sec>

Journal

  • Head & Neck

    Head & Neck 25 (12), 1057-1070, 2003-07-15

    Wiley

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