Assessment of relative brain iron concentrations using <i>T</i><sub>2</sub>‐weighted and <i>T</i><sub>2</sub>*‐weighted MRI at 3 Tesla
書誌事項
- 公開日
- 1994-09
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1002/mrm.1910320309
- 公開者
- Wiley
この論文をさがす
説明
<jats:title>Abstract</jats:title><jats:p>In this paper a new method is presented for the relative assessment of brain iron concentrations based on the evaluation of T<jats:sub>2</jats:sub> and T<jats:sub>2</jats:sub>* ‐weighted images. A multiecho sequence is employed for rapid measurement of T<jats:sub>2</jats:sub> and T<jats:sub>2</jats:sub>*, enabling calculation of the line broadening effect ( T<jats:sub>2</jats:sub>′). Several groups have failed to show a correlation between T<jats:sub>2</jats:sub> and brain iron content. However, quantification of T<jats:sub>2</jats:sub>′, and the associated relaxation rate R<jats:sub>2</jats:sub>′, may provide a more specific relative measure of brain iron concentration. This may find application in the study of brain diseases, which cause associated changes in brain iron levels. A new method of field inhomogeneity correction is presented that allows the separation of global and local field inhomogeneities, leading to more accurate T<jats:sub>2</jats:sub>* measurements and hence, T<jats:sub>2</jats:sub>′ values. The combination of T<jats:sub>2</jats:sub>*, and T<jats:sub>2</jats:sub>‐weighted MRI methods enables the differentiation of Parlkinson's disease patients from normal age‐matched controls based on differences in iron content within the substantia nigra.</jats:p>
収録刊行物
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- Magnetic Resonance in Medicine
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Magnetic Resonance in Medicine 32 (3), 335-341, 1994-09
Wiley