The HDAC3–SMARCA4–miR-27a axis promotes expression of the <i>PAX3:FOXO1</i> fusion oncogene in rhabdomyosarcoma

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  • Narendra Bharathy
    Children’s Cancer Therapy Development Institute, Beaverton, OR 97005, USA.
  • Noah E. Berlow
    Children’s Cancer Therapy Development Institute, Beaverton, OR 97005, USA.
  • Eric Wang
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
  • Jinu Abraham
    Department of Pediatrics, Oregon Health & Science University, Portland, OR 97239, USA.
  • Teagan P. Settelmeyer
    Children’s Cancer Therapy Development Institute, Beaverton, OR 97005, USA.
  • Jody E. Hooper
    Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA.
  • Matthew N. Svalina
    Children’s Cancer Therapy Development Institute, Beaverton, OR 97005, USA.
  • Yoshihiro Ishikawa
    Research Center, Shriners Hospital for Children, Portland, OR 97239, USA.
  • Keith Zientek
    Research Center, Shriners Hospital for Children, Portland, OR 97239, USA.
  • Zia Bajwa
    Children’s Cancer Therapy Development Institute, Beaverton, OR 97005, USA.
  • Martin W. Goros
    Department of Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, TX 78229, USA.
  • Brian S. Hernandez
    Department of Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, TX 78229, USA.
  • Johannes E. Wolff
    Department of Pediatric Hematology Oncology and Blood and Marrow Transplantation, Cleveland Clinic Children’s, Cleveland, OH 44195, USA.
  • Michelle A. Rudek
    Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA.
  • Linping Xu
    Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA.
  • Nicole M. Anders
    Department of Oncology, School of Medicine, Johns Hopkins University, Baltimore, MD 21231, USA.
  • Ranadip Pal
    Electrical and Computer Engineering, Texas Tech University, Lubbock, TX 79409, USA.
  • Alexandria P. Harrold
    Children’s Cancer Therapy Development Institute, Beaverton, OR 97005, USA.
  • Angela M. Davies
    Champions Oncology, Rockville, MD 20850, USA.
  • Arya Ashok
    Champions Oncology, Rockville, MD 20850, USA.
  • Darnell Bushby
    Champions Oncology, Rockville, MD 20850, USA.
  • Maria Mancini
    Champions Oncology, Rockville, MD 20850, USA.
  • Christopher Noakes
    Champions Oncology, Rockville, MD 20850, USA.
  • Neal C. Goodwin
    Champions Oncology, Rockville, MD 20850, USA.
  • Peter Ordentlich
    Syndax Pharmaceuticals, Waltham, MA 02451, USA.
  • James Keck
    The Jackson Laboratory, Sacramento, CA 95838, USA.
  • Douglas S. Hawkins
    Seattle Children’s Hospital, Seattle, WA 98105, USA.
  • Erin R. Rudzinski
    Seattle Children’s Hospital, Seattle, WA 98105, USA.
  • Bishwanath Chatterjee
    Cancer Molecular Pathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892-1500, USA.
  • Hans Peter Bächinger
    Research Center, Shriners Hospital for Children, Portland, OR 97239, USA.
  • Frederic G. Barr
    Cancer Molecular Pathology Section, Laboratory of Pathology, National Cancer Institute, Bethesda, MD 20892-1500, USA.
  • Jennifer Liddle
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Benjamin A. Garcia
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Atiya Mansoor
    Department of Pathology, Oregon Health & Science University, Portland, OR 97239, USA.
  • Theodore J. Perkins
    Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa K1H 8L6, Canada.
  • Christopher R. Vakoc
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
  • Joel E. Michalek
    Department of Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, TX 78229, USA.
  • Charles Keller
    Children’s Cancer Therapy Development Institute, Beaverton, OR 97005, USA.

説明

<jats:p>The HDAC inhibitor entinostat sensitizes a subset of rhabdomyosarcomas to chemotherapy.</jats:p>

収録刊行物

  • Science Signaling

    Science Signaling 11 (557), eaau7632-, 2018-11-20

    American Association for the Advancement of Science (AAAS)

被引用文献 (2)*注記

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