Synthesis of Oxygen Heterocycles via Aromatic C-O Bond Formation Using Arynes
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- Hideto Miyabe
- School of Pharmacy, Hyogo University of Health Sciences, 1-3-6, Minatojima, Chuo-ku, Kobe 650-8530, Japan
書誌事項
- 公開日
- 2015-07-09
- 権利情報
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- https://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.3390/molecules200712558
- 公開者
- MDPI AG
説明
<jats:p>Most of the synthetic approaches to the benzo-fused heterocycles containing an oxygen atom have involved the use of phenol derivatives as a starting material. This review highlights the new synthetic approaches involving the aromatic C-O bond-forming process using arynes. The insertion of arynes into the C=O bond gives the unstable intermediates, [2 + 2] cycloaddition-type adducts, which can be easily converted into a variety of oxygen atom-containing heterocycles in a single operation. In this review, the syntheses of oxygen heterocycles, such as coumarin, chromene, xanthene, dihydrobenzofuran and benzofuran derivatives, via the insertion of arynes into the C=O bond of aldehydes or formamides are summarized.</jats:p>
収録刊行物
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- Molecules
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Molecules 20 (7), 12558-12575, 2015-07-09
MDPI AG