Microscale technologies for tissue engineering and biology

DOI Web Site 被引用文献48件
  • Ali Khademhosseini
    *Harvard–Massachusetts Institute of Technology Division of Health Sciences and Technology and
  • Robert Langer
    *Harvard–Massachusetts Institute of Technology Division of Health Sciences and Technology and
  • Jeffrey Borenstein
    The Charles Stark Draper Laboratory, Cambridge, MA 02139; and
  • Joseph P. Vacanti
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114

説明

<jats:p> Microscale technologies are emerging as powerful tools for tissue engineering and biological studies. In this review, we present an overview of these technologies in various tissue engineering applications, such as for fabricating 3D microfabricated scaffolds, as templates for cell aggregate formation, or for fabricating materials in a spatially regulated manner. In addition, we give examples of the use of microscale technologies for controlling the cellular microenvironment <jats:italic>in vitro</jats:italic> and for performing high-throughput assays. The use of microfluidics, surface patterning, and patterned cocultures in regulating various aspects of cellular microenvironment is discussed, as well as the application of these technologies in directing cell fate and elucidating the underlying biology. Throughout this review, we will use specific examples where available and will provide trends and future directions in the field. </jats:p>

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