Mechanochemical Activation of Zinc and Application to Negishi Cross‐Coupling

Qun Cao, Joseph L. Howard, Emilie Wheatley, Duncan L. Browne

doi:10.1002/ange.201806480

Mechanochemical Activation of Zinc and Application to Negishi Cross‐Coupling

DOI Web Site Web Site 被引用文献3件

Qun Cao

School of Chemistry Cardiff University Main Building, Park Place Cardiff CF10 3EQ UK
Joseph L. Howard

School of Chemistry Cardiff University Main Building, Park Place Cardiff CF10 3EQ UK
Emilie Wheatley

School of Chemistry Cardiff University Main Building, Park Place Cardiff CF10 3EQ UK
Duncan L. Browne

School of Chemistry Cardiff University Main Building, Park Place Cardiff CF10 3EQ UK

書誌事項

公開日: 2018-08-02

権利情報

http://creativecommons.org/licenses/by/4.0/

DOI

10.1002/ange.201806480

公開者: Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>A form independent activation of zinc, concomitant generation of organozinc species and engagement in a Negishi cross‐coupling reaction via mechanochemical methods is reported. The reported method exhibits a broad substrate scope for both C(sp<jats:sup>3</jats:sup>)–C(sp<jats:sup>2</jats:sup>) and C(sp<jats:sup>2</jats:sup>)–C(sp<jats:sup>2</jats:sup>) couplings and is tolerant to many important functional groups. The method may offer broad reaching opportunities for the in situ generation organometallic compounds from base metals and their concomitant engagement in synthetic reactions via mechanochemical methods.</jats:p>