Immune Protection against Virus Challenge in Aging Mice Is Not Affected by Latent Herpesviral Infections
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- Thomas F. Marandu
- Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany
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- Jennifer D. Oduro
- Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany
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- Lisa Borkner
- Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany
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- Iryna Dekhtiarenko
- Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany
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- Jennifer L. Uhrlaub
- Department of Immunobiology and the Arizona Center on Aging, University of Arizona College of Medicine, Tucson, Arizona, USA
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- Anja Drabig
- Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany
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- Andrea Kröger
- Research Group Innate Immunity and Infection, HZI, Braunschweig, Germany
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- Janko Nikolich-Zugich
- Oregon Health and Science University (OHSU), Portland, Oregon, USA
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- Luka Cicin-Sain
- Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany
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- K. Frueh
- editor
説明
<jats:title>ABSTRACT</jats:title> <jats:p>Latent herpesvirus infections alter immune homeostasis. To understand if this results in aging-related loss of immune protection against emerging infections, we challenged old mice carrying latent mouse cytomegalovirus (CMV), herpes simplex virus 1 (HSV-1), and/or murine gammaherpesvirus 68 (MHV-68) with influenza virus, West Nile virus (WNV), or vesicular stomatitis virus (VSV). We observed no increase in mortality or weight loss compared to results seen with herpesvirus-negative counterparts and a relative but not absolute reduction in CD8 responses to acute infections. Therefore, the presence of herpesviruses does not appear to increase susceptibility to emerging infections in aging patients.</jats:p>
収録刊行物
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- Journal of Virology
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Journal of Virology 89 (22), 11715-11717, 2015-11-15
American Society for Microbiology