Proinflammatory cytokine release by peripheral blood mononuclear cells from patients with acute pancreatitis

DOI PDF Web Site 被引用文献7件
  • A C de Beaux
    University Department of Surgery, Royal Infirmary , Edinburgh EH3 9YW,
  • J A Ross
    University Department of Surgery, Royal Infirmary , Edinburgh EH3 9YW,
  • J P Maingay
    University Department of Surgery, Royal Infirmary , Edinburgh EH3 9YW,
  • K C H Fearon
    University Department of Surgery, Royal Infirmary , Edinburgh EH3 9YW,
  • D C Carter
    University Department of Surgery, Royal Infirmary , Edinburgh EH3 9YW,

書誌事項

公開日
1996-08-01
権利情報
  • https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
DOI
  • 10.1002/bjs.1800830811
公開者
Oxford University Press (OUP)

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<jats:title>Abstract</jats:title> <jats:p>Proinflammatory cytokine release was measured from peripheral blood mononuclear cells (PBMCs) isolated from six volunteers and, on admission, from 16 patients with acute pancreatitis. Tumour necrosis factor (TNF) release in patients did not differ significantly from that of volunteers, whereas both interleukin (IL) 6 and IL-8 release in patients was raised when compared with that in the volunteer group (mean(s.e.m.) IL-6 20·7(4·6) versus 9·3(1·7) ng/ml, P = 0·03; IL-8 283(40) versus 128(22) ng/ml, P = 0·04). When variation in white cell count was accounted for, IL-6 and IL-8 release but not that of TNF was significantly greater in patients with severe disease than in those with mild disease. These results point to a complex upregulation of proinflammatory cytokine release from PBMCs in patients with acute pancreatitis, components of which relate to the clinical progress of the disease.</jats:p>

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