Recombination signal sequence-binding protein Jκ alters mesodermal cell fate decisions by suppressing cardiomyogenesis

DOI Web Site PubMed 被引用文献7件 オープンアクセス
  • Timm Schroeder
    GSF-National Research Center for Environment and Health, Institute of Clinical Molecular Biology and Tumor Genetics, Marchioninistrasse 25, 81377 Munich, Germany; Departments of Molecular Genetics and Medical Chemistry, Kyoto University, Sakyo-ku, Kyoto 606, Japan Asia; and Laboratory for Stem Cell Biology, Riken Center for Developmental Biology, Minatojima-minamimachi 2-2-3, Chuoku, Kobe 650-0047, Japan Asia
  • Stuart T. Fraser
    GSF-National Research Center for Environment and Health, Institute of Clinical Molecular Biology and Tumor Genetics, Marchioninistrasse 25, 81377 Munich, Germany; Departments of Molecular Genetics and Medical Chemistry, Kyoto University, Sakyo-ku, Kyoto 606, Japan Asia; and Laboratory for Stem Cell Biology, Riken Center for Developmental Biology, Minatojima-minamimachi 2-2-3, Chuoku, Kobe 650-0047, Japan Asia
  • Minetaro Ogawa
    GSF-National Research Center for Environment and Health, Institute of Clinical Molecular Biology and Tumor Genetics, Marchioninistrasse 25, 81377 Munich, Germany; Departments of Molecular Genetics and Medical Chemistry, Kyoto University, Sakyo-ku, Kyoto 606, Japan Asia; and Laboratory for Stem Cell Biology, Riken Center for Developmental Biology, Minatojima-minamimachi 2-2-3, Chuoku, Kobe 650-0047, Japan Asia
  • Satomi Nishikawa
    GSF-National Research Center for Environment and Health, Institute of Clinical Molecular Biology and Tumor Genetics, Marchioninistrasse 25, 81377 Munich, Germany; Departments of Molecular Genetics and Medical Chemistry, Kyoto University, Sakyo-ku, Kyoto 606, Japan Asia; and Laboratory for Stem Cell Biology, Riken Center for Developmental Biology, Minatojima-minamimachi 2-2-3, Chuoku, Kobe 650-0047, Japan Asia
  • Chio Oka
    GSF-National Research Center for Environment and Health, Institute of Clinical Molecular Biology and Tumor Genetics, Marchioninistrasse 25, 81377 Munich, Germany; Departments of Molecular Genetics and Medical Chemistry, Kyoto University, Sakyo-ku, Kyoto 606, Japan Asia; and Laboratory for Stem Cell Biology, Riken Center for Developmental Biology, Minatojima-minamimachi 2-2-3, Chuoku, Kobe 650-0047, Japan Asia
  • Georg W. Bornkamm
    GSF-National Research Center for Environment and Health, Institute of Clinical Molecular Biology and Tumor Genetics, Marchioninistrasse 25, 81377 Munich, Germany; Departments of Molecular Genetics and Medical Chemistry, Kyoto University, Sakyo-ku, Kyoto 606, Japan Asia; and Laboratory for Stem Cell Biology, Riken Center for Developmental Biology, Minatojima-minamimachi 2-2-3, Chuoku, Kobe 650-0047, Japan Asia
  • Shin-Ichi Nishikawa
    GSF-National Research Center for Environment and Health, Institute of Clinical Molecular Biology and Tumor Genetics, Marchioninistrasse 25, 81377 Munich, Germany; Departments of Molecular Genetics and Medical Chemistry, Kyoto University, Sakyo-ku, Kyoto 606, Japan Asia; and Laboratory for Stem Cell Biology, Riken Center for Developmental Biology, Minatojima-minamimachi 2-2-3, Chuoku, Kobe 650-0047, Japan Asia
  • Tasuku Honjo
    GSF-National Research Center for Environment and Health, Institute of Clinical Molecular Biology and Tumor Genetics, Marchioninistrasse 25, 81377 Munich, Germany; Departments of Molecular Genetics and Medical Chemistry, Kyoto University, Sakyo-ku, Kyoto 606, Japan Asia; and Laboratory for Stem Cell Biology, Riken Center for Developmental Biology, Minatojima-minamimachi 2-2-3, Chuoku, Kobe 650-0047, Japan Asia
  • Ursula Just
    GSF-National Research Center for Environment and Health, Institute of Clinical Molecular Biology and Tumor Genetics, Marchioninistrasse 25, 81377 Munich, Germany; Departments of Molecular Genetics and Medical Chemistry, Kyoto University, Sakyo-ku, Kyoto 606, Japan Asia; and Laboratory for Stem Cell Biology, Riken Center for Developmental Biology, Minatojima-minamimachi 2-2-3, Chuoku, Kobe 650-0047, Japan Asia

書誌事項

公開日
2003-03-24
DOI
  • 10.1073/pnas.0438008100
公開者
Proceedings of the National Academy of Sciences

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<jats:p>The transcription factor recombination signal sequence-binding protein Jκ (RBP-J) is a key downstream element in the signaling pathway of all four mammalian Notch receptors that are critically involved in the control of embryonic and adult development. RBP-J-deficient mice display complex defects and die around day 9.5 postcoitum. Here, we investigate the function of RBP-J in the development of mesodermal cell lineages by using the OP9 stroma coculture system. RBP-J-deficient embryonic stem (ES) cells gave rise to cardiomyocytes, endothelial cells, and primitive and definitive hematopoietic cells. Thus, RBP-J-mediated signals are not required for generation of these cell types. However, when compared with parental RBP-J-expressing ES cells, cardiomyogenesis derived from RBP-J-deficient ES cells was increased. Repression over the cardiogenic pathway was restored by expressing RBP-J in RBP-J-deficient ES cells. Our data indicate that Notch signaling via RBP-J plays an important role for the correct specification of myocardial cell fates.</jats:p>

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