The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors

DOI HANDLE PDF Web Site Web Site ほか1件をすべて表示 一部だけ表示 被引用文献16件

書誌事項

公開日
1998-10
権利情報
  • http://www.springer.com/tdm
DOI
  • 10.1038/26989
公開者
Springer Science and Business Media LLC

この論文をさがす

説明

Tcf/Lef transcription factors mediate signalling from Wingless/Wnt proteins by recruiting Armadillo/beta-catenin as a transcriptional co-activator. However, studies of Drosophila, Xenopus and Caenorhabditis elegans have indicated that Tcf factors may also be transcriptional repressors. Here we show that Tcf factors physically interact with members of the Groucho family of transcriptional repressors. In transient transfection assays, the Xenopus Groucho homologue XGrg-4 inhibited activation of transcription of synthetic Tcf reporter genes. In contrast, the naturally truncated Groucho-family member XGrg-5 enhanced transcriptional activation. Injection of XGrg-4 into Xenopus embryos repressed transcription of Siamois and Xnr-3, endogenous targets of beta-catenin-Tcf. Dorsal injection of XGrg-4 had a ventralizing effect on Xenopus embryos. Secondary-axis formation induced by a dominant-positive Armadillo-Tcf fusion protein was inhibited by XGrg-4 and enhanced by XGrg-5. These data indicate that expression of Tcf target genes is regulated by a balance between Armadillo and Groucho.

収録刊行物

  • Nature

    Nature 395 (6702), 608-612, 1998-10

    Springer Science and Business Media LLC

被引用文献 (16)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ