Virus‐Like Particle Engineering: From Rational Design to Versatile Applications
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- Xuanwei Ding
- Department of Chemical Engineering Tsinghua University Beijing China
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- Dong Liu
- Department of Chemical Engineering Tsinghua University Beijing China
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- George Booth
- Department of Chemical Engineering Imperial College London London UK
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- Wei Gao
- Department of Chemical Engineering Tsinghua University Beijing China
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- Yuan Lu
- Department of Chemical Engineering Tsinghua University Beijing China
抄録
<jats:sec><jats:label /><jats:p>As mimicking natural virus structures, virus‐like particles (VLPs) have evolved to become a widely accepted technology used for humans which are safe, highly efficacious, and profitable. Several remarkable advantages have been achieved to revolutionize the molecule delivery for diverse applications in nanotechnology, biotechnology, and medicine. Here, the rational structure design, manufacturing process, functionalization strategy, and emerging applications of VLPs is reviewed. The situation and challenges in the VLP engineering, the key development orientation, and future applications have been discussed. To develop a good VLP design concept, the virus/VLP‐host interactions need to be examined and the screening methods of the VLP stabilization factors need to be established. The functionalization toolbox can be expanded to fabricate smart, robust, and multifunctional VLPs. Novel robust VLP manufacturing platforms are required to deliver vaccines in resource‐poor regions with a significant reduction in the production time and cost. The future applications of VLPs are always driven by the development of emerging technologies and new requirements of modern life.</jats:p></jats:sec>
収録刊行物
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- Biotechnology Journal
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Biotechnology Journal 13 (5), 1-, 2018-03-05
Wiley