Antisecretory and antiulcer effect of the H<sub>2</sub>‐receptor antagonist famotidine in the rat: comparison with ranitidine

DOI Web Site Web Site 被引用文献1件

書誌事項

公開日
1987-09
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1111/j.1476-5381.1987.tb11307.x
公開者
Wiley

この論文をさがす

説明

<jats:p><jats:list list-type="explicit-label"> <jats:list-item><jats:p>The effects of the new H<jats:sub>2</jats:sub>‐receptor antagonist famotidine, administered orally, on gastric secretion and emptying as well as on experimentally‐induced gastric and duodenal ulcers were studied in the rat. Ranitidine was used as a reference compound.</jats:p></jats:list-item> <jats:list-item><jats:p>Both compounds inhibited acid secretion in a dose‐dependent manner. Calculated ED<jats:sub>50</jats:sub> values were 0.80 and 6.84 mg kg<jats:sup>−1</jats:sup> for famotidine and ranitidine, respectively. However, the duration of the antisecretory action was the same for both drugs.</jats:p></jats:list-item> <jats:list-item><jats:p>The effect of the two drugs, administered at equiactive antisecretory doses, on gastric emptying was different. Ranitidine significantly accelerated the emptying rate whereas famotidine had no effect.</jats:p></jats:list-item> <jats:list-item><jats:p>Famotidine reduced, in a dose‐dependent manner, ulcer incidence in stomachs of dimaprit‐treated rats and in duodena of cysteamine‐treated animals with a potency respectively 2 and 7 times higher than that of ranitidine.</jats:p></jats:list-item> <jats:list-item><jats:p>Famotidine is therefore an effective antisecretory and untiulcer compound. Its potency, but not its efficacy, is higher than that of ranitidine. Moreover, the duration of the antisecretory action is virtually the same for both drugs.</jats:p></jats:list-item> </jats:list></jats:p>

収録刊行物

被引用文献 (1)*注記

もっと見る

問題の指摘

ページトップへ