Participation of cathepsin L on bone resorption

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書誌事項

公開日
1993-04-26
権利情報
  • http://onlinelibrary.wiley.com/termsAndConditions#vor
DOI
  • 10.1016/0014-5793(93)80118-e
公開者
Wiley

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説明

<jats:p>The proteinase responsible for bone collagen degradation in osteo‐resorption was examined. The bone pit formation induced by parathyroid hormone (PTH) was markedly suppressed by leupeptin, E‐64 and cystatin A, while no inhibition was observed by CA‐074, a specific inhibitor of cathepsin B. Pig leucocyte cysteine proteinase inhibitor (PLCPI), a specific inhibitor of cathepsin L, and chymostatin, a selective inhibitor of cathepsin L, completely inhibited the pit formation. Cathepsin L activity in osteoclasts was much higher than the other cathepsin activities. Serum calcium in rats placed on a low calcium diet was decreased by treatment of E‐64 or cystatin A, but not by CA‐074. These findings suggest that cathepsin L is the main proteinase responsible for bone collagen degradation.</jats:p>

収録刊行物

  • FEBS Letters

    FEBS Letters 321 (2-3), 247-250, 1993-04-26

    Wiley

被引用文献 (3)*注記

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