Mechanisms of Estrogen Action

DOI Web Site 被引用文献37件
  • Stefan Nilsson
    KaroBio AB and Departments of Biosciences and of Medical Nutrition, Karolinska Institute, NOVUM; Department of Pathology, Huddinge Hospital, Huddinge, Sweden; and Institute of Biomedicin Department of Anatomy, University of Turku, Turku, Finland
  • Sari Mäkelä
    KaroBio AB and Departments of Biosciences and of Medical Nutrition, Karolinska Institute, NOVUM; Department of Pathology, Huddinge Hospital, Huddinge, Sweden; and Institute of Biomedicin Department of Anatomy, University of Turku, Turku, Finland
  • Eckardt Treuter
    KaroBio AB and Departments of Biosciences and of Medical Nutrition, Karolinska Institute, NOVUM; Department of Pathology, Huddinge Hospital, Huddinge, Sweden; and Institute of Biomedicin Department of Anatomy, University of Turku, Turku, Finland
  • Michel Tujague
    KaroBio AB and Departments of Biosciences and of Medical Nutrition, Karolinska Institute, NOVUM; Department of Pathology, Huddinge Hospital, Huddinge, Sweden; and Institute of Biomedicin Department of Anatomy, University of Turku, Turku, Finland
  • Jane Thomsen
    KaroBio AB and Departments of Biosciences and of Medical Nutrition, Karolinska Institute, NOVUM; Department of Pathology, Huddinge Hospital, Huddinge, Sweden; and Institute of Biomedicin Department of Anatomy, University of Turku, Turku, Finland
  • Göran Andersson
    KaroBio AB and Departments of Biosciences and of Medical Nutrition, Karolinska Institute, NOVUM; Department of Pathology, Huddinge Hospital, Huddinge, Sweden; and Institute of Biomedicin Department of Anatomy, University of Turku, Turku, Finland
  • Eva Enmark
    KaroBio AB and Departments of Biosciences and of Medical Nutrition, Karolinska Institute, NOVUM; Department of Pathology, Huddinge Hospital, Huddinge, Sweden; and Institute of Biomedicin Department of Anatomy, University of Turku, Turku, Finland
  • Katarina Pettersson
    KaroBio AB and Departments of Biosciences and of Medical Nutrition, Karolinska Institute, NOVUM; Department of Pathology, Huddinge Hospital, Huddinge, Sweden; and Institute of Biomedicin Department of Anatomy, University of Turku, Turku, Finland
  • Margaret Warner
    KaroBio AB and Departments of Biosciences and of Medical Nutrition, Karolinska Institute, NOVUM; Department of Pathology, Huddinge Hospital, Huddinge, Sweden; and Institute of Biomedicin Department of Anatomy, University of Turku, Turku, Finland
  • Jan-Åke Gustafsson
    KaroBio AB and Departments of Biosciences and of Medical Nutrition, Karolinska Institute, NOVUM; Department of Pathology, Huddinge Hospital, Huddinge, Sweden; and Institute of Biomedicin Department of Anatomy, University of Turku, Turku, Finland

説明

<jats:p>Our appreciation of the physiological functions of estrogens and the mechanisms through which estrogens bring about these functions has changed during the past decade. Just as transgenic mice were produced in which estrogen receptors had been inactivated and we thought that we were about to understand the role of estrogen receptors in physiology and pathology, it was found that there was not one but two distinct and functional estrogen receptors, now called ERα and ERβ. Transgenic mice in which each of the receptors or both the receptors are inactive have revealed a much broader role for estrogens in the body than was previously thought. This decade also saw the description of a male patient who had no functional ERα and whose continued bone growth clearly revealed an important function of estrogen in men. The importance of estrogen in both males and females was also demonstrated in the laboratory in transgenic mice in which the aromatase gene was inactivated. Finally, crystal structures of the estrogen receptors with agonists and antagonists have revealed much about how ligand binding influences receptor conformation and how this conformation influences interaction of the receptor with coactivators or corepressors and hence determines cellular response to ligands.</jats:p>

収録刊行物

  • Physiological Reviews

    Physiological Reviews 81 (4), 1535-1565, 2001-01-10

    American Physiological Society

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