Induction and Repair of DNA Lesions in Cultured Human Melanoma Cells Exposed to a Nitrogen-ion Beam
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- K. Eguchi
- Institute of Basic Medical Sciences, University of Tsukuba, Sakuramura, Ibaraki, 305, Japan
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- T. Inada
- The Institute of Physical and Chemical Research, 2-1, Hirosawa, Wakoshi, Saitama, 351-01, Japan
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- M. Yaguchi
- Institute of Basic Medical Sciences, University of Tsukuba, Sakuramura, Ibaraki, 305, Japan
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- S. Satoh
- The Institute of Physical and Chemical Research, 2-1, Hirosawa, Wakoshi, Saitama, 351-01, Japan
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- I. Kaneko
- Institute of Basic Medical Sciences, University of Tsukuba, Sakuramura, Ibaraki, 305, Japan
書誌事項
- 公開日
- 1987-01
- DOI
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- 10.1080/09553008714551541
- 公開者
- Informa UK Limited
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説明
Induction and repair kinetics of DNA lesions after exposure to nitrogen ions (N-ions) were studied in comparison to those after 180 kVp X-rays. DNA lesions in human melanoma cells (HMV-I) irradiated with 95 MeV N-ions (0-6 Gy, l.e.t.D = 530 keV micron-1 or with X-rays (0.9 Gy) were assayed by alkaline elution. The N-ion r.b.e. for DNA lesion induction was approximately 0.7. About 85 per cent of the lesions induced by N ions were rejoined with a time-course similar to the rejoining of DNA lesions produced by X-rays. These lesions were considered to be induced by delta-rays around the N-ion tracks. The fraction of residual DNA lesions remaining after a 6 h post-irradiation incubation was higher for N-ions than for X-rays. Unlike the case for X-rays, DNA-protein crosslinks were included in the residual DNA lesions after N-ion irradiation.
収録刊行物
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- International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine
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International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine 52 (1), 115-123, 1987-01
Informa UK Limited
