Virus–virus interactions impact the population dynamics of influenza and the common cold
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- Sema Nickbakhsh
- MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, G61 1QH Glasgow, United Kingdom;
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- Colette Mair
- MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, G61 1QH Glasgow, United Kingdom;
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- Louise Matthews
- Boyd Orr Centre for Population and Ecosystem Health, Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, G12 8QQ Glasgow, United Kingdom;
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- Richard Reeve
- Boyd Orr Centre for Population and Ecosystem Health, Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, G12 8QQ Glasgow, United Kingdom;
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- Paul C. D. Johnson
- Boyd Orr Centre for Population and Ecosystem Health, Institute of Biodiversity, Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, G12 8QQ Glasgow, United Kingdom;
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- Fiona Thorburn
- The Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde, G51 4TF Glasgow, United Kingdom;
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- Beatrix von Wissmann
- Public Health, NHS Greater Glasgow and Clyde, G12 0XH Glasgow, United Kingdom;
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- Arlene Reynolds
- Health Protection Scotland, NHS National Services Scotland, G2 6QE Glasgow, United Kingdom;
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- James McMenamin
- Health Protection Scotland, NHS National Services Scotland, G2 6QE Glasgow, United Kingdom;
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- Rory N. Gunson
- West of Scotland Specialist Virology Centre, NHS Greater Glasgow and Clyde, G31 2ER Glasgow, United Kingdom
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- Pablo R. Murcia
- MRC-University of Glasgow Centre for Virus Research, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, G61 1QH Glasgow, United Kingdom;
書誌事項
- 公開日
- 2019-12-16
- 権利情報
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- https://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.1073/pnas.1911083116
- 公開者
- Proceedings of the National Academy of Sciences
この論文をさがす
説明
<jats:title>Significance</jats:title> <jats:p>When multiple pathogens cocirculate this can lead to competitive or cooperative forms of pathogen–pathogen interactions. It is believed that such interactions occur among cold and flu viruses, perhaps through broad-acting immunity, resulting in interlinked epidemiological patterns of infection. However, to date, quantitative evidence has been limited. We analyzed a large collection of diagnostic reports collected over multiple years for 11 respiratory viruses. Our analyses provide strong statistical support for the existence of interactions among respiratory viruses. Using computer simulations, we found that very short-lived interferences may explain why common cold infections are less frequent during flu seasons. Improved understanding of how the epidemiology of viral infections is interlinked can help improve disease forecasting and evaluation of disease control interventions.</jats:p>
収録刊行物
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- Proceedings of the National Academy of Sciences
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Proceedings of the National Academy of Sciences 116 (52), 27142-27150, 2019-12-16
Proceedings of the National Academy of Sciences