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- Richard J. McKenney
- Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA.
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- Walter Huynh
- Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA.
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- Marvin E. Tanenbaum
- Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA.
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- Gira Bhabha
- Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA.
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- Ronald D. Vale
- Department of Cellular and Molecular Pharmacology and the Howard Hughes Medical Institute, University of California, San Francisco, CA 94158, USA.
書誌事項
- 公開日
- 2014-07-18
- DOI
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- 10.1126/science.1254198
- 公開者
- American Association for the Advancement of Science (AAAS)
この論文をさがす
説明
<jats:title>How dynein makes the right moves</jats:title> <jats:p> The molecular motor cytoplasmic dynein moves a wide range of different intracellular cargoes. Dynein's activity in vivo requires another protein, dynactin, but exactly why that should be has been very unclear. Although in vitro experiments have provided some evidence that dynactin increases dynein's processivity, the resulting dynein motility has never come close to matching dynein's cargo-transporting activity in living cells. Now, McKenney <jats:italic>et al.</jats:italic> show that tripartite complexes of dynein, dynactin, and an adaptor molecule are highly processive in vitro, moving the sort of distances that dynein transports cargo in vivo (see the Perspective by Allan). </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6194" page="337" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1254198">337</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6194" page="271" related-article-type="in-this-issue" vol="345" xlink:href="10.1126/science.1257245">271</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 345 (6194), 337-341, 2014-07-18
American Association for the Advancement of Science (AAAS)