Small-Conductance Ca<sup>2+</sup>-Activated K<sup>+</sup> Channels: Form and Function
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- John P. Adelman
- Vollum Institute, Oregon Health & Science University, Portland, Oregon 97239;
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- James Maylie
- Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon 97239;
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- Pankaj Sah
- The Queensland Brain Institute, The University of Queensland, Brisbane, Queensland, 4072, Australia;
抄録
<jats:p> Small-conductance Ca<jats:sup>2+</jats:sup>-activated K<jats:sup>+</jats:sup> channels (SK channels) are widely expressed throughout the central nervous system. These channels are activated solely by increases in intracellular Ca<jats:sup>2+</jats:sup>. SK channels are stable macromolecular complexes of the ion pore–forming subunits with calmodulin, which serves as the intrinsic Ca<jats:sup>2+</jats:sup> gating subunit, as well as with protein kinase CK2 and protein phosphatase 2A, which modulate Ca<jats:sup>2+</jats:sup> sensitivity. Well-known for their roles in regulating somatic excitability in central neurons, SK channels are also expressed in the postsynaptic membrane of glutamatergic synapses, where their activation and regulated trafficking modulate synaptic transmission and the induction and expression of synaptic plasticity, thereby affecting learning and memory. In this review we discuss the molecular and functional properties of SK channels and their physiological roles in central neurons. </jats:p>
収録刊行物
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- Annual Review of Physiology
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Annual Review of Physiology 74 (1), 245-269, 2012-03-17
Annual Reviews