Plasma cell toll‐like receptor (TLR) expression differs from that of B cells, and plasma cell TLR triggering enhances immunoglobulin production
書誌事項
- 公開日
- 2009-11-06
- 権利情報
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- http://onlinelibrary.wiley.com/termsAndConditions#vor
- DOI
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- 10.1111/j.1365-2567.2009.03143.x
- 公開者
- Wiley
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説明
<jats:title>Summary</jats:title><jats:p>Toll‐like receptors (TLRs) are key receptors of the innate immune system and show cell subset‐specific expression. We investigated the messenger RNA (mRNA) expression of <jats:italic>TLR</jats:italic> genes in human haematopoietic stem cells (HSC), in naïve B cells, in memory B cells, in plasma cells from palatine tonsils and in plasma cells from peripheral blood. HSC and plasma cells showed unrestricted expression of <jats:italic>TLR1–TLR9</jats:italic>, in contrast to B cells which lacked <jats:italic>TLR3</jats:italic>, <jats:italic>TLR4</jats:italic> and <jats:italic>TLR8</jats:italic> but expressed mRNA of all other <jats:italic>TLR</jats:italic>s. We demonstrated, for the first time, that TLR triggering of terminally differentiated plasma cells augments immunoglobulin production. Thus, boosting the immediate antibody response by plasma cells upon pathogen recognition may point to a novel role of TLRs.</jats:p>
収録刊行物
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- Immunology
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Immunology 128 (4), 573-579, 2009-11-06
Wiley