Structural Diversity and Biological Activities of Novel Secondary Metabolites from Endophytes
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- Han Gao
- Department of Natural Medicine and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao 266021, China
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- Gang Li
- Department of Natural Medicine and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao 266021, China
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- Hong-Xiang Lou
- Department of Natural Medicine and Pharmacognosy, School of Pharmacy, Qingdao University, Qingdao 266021, China
書誌事項
- 公開日
- 2018-03-13
- 権利情報
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- https://creativecommons.org/licenses/by/4.0/
- DOI
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- 10.3390/molecules23030646
- 公開者
- MDPI AG
説明
<jats:p>Exploration of structurally novel natural products greatly facilitates the discovery of biologically active pharmacophores that are biologically validated starting points for the development of new drugs. Endophytes that colonize the internal tissues of plant species, have been proven to produce a large number of structurally diverse secondary metabolites. These molecules exhibit remarkable biological activities, including antimicrobial, anticancer, anti-inflammatory and antiviral properties, to name but a few. This review surveys the structurally diverse natural products with new carbon skeletons, unusual ring systems, or rare structural moieties that have been isolated from endophytes between 1996 and 2016. It covers their structures and bioactivities. Biosynthesis and/or total syntheses of some important compounds are also highlighted. Some novel secondary metabolites with marked biological activities might deserve more attention from chemists and biologists in further studies.</jats:p>
収録刊行物
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- Molecules
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Molecules 23 (3), 646-, 2018-03-13
MDPI AG