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- Adam R. Spaulding
- Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
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- Wilmara Salgado-Pabón
- Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
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- Petra L. Kohler
- Department of Microbiology, University of Minnesota Medical School, Minneapolis, Minnesota, USA
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- Alexander R. Horswill
- Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
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- Donald Y. M. Leung
- Department of Pediatrics, National Jewish Health, Denver, Colorado, USA
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- Patrick M. Schlievert
- Department of Microbiology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
説明
<jats:title>SUMMARY</jats:title><jats:p>This review begins with a discussion of the large family of<jats:named-content content-type="genus-species">Staphylococcus aureus</jats:named-content>and beta-hemolytic streptococcal pyrogenic toxin T lymphocyte superantigens from structural and immunobiological perspectives. With this as background, the review then discusses the major known and possible human disease associations with superantigens, including associations with toxic shock syndromes, atopic dermatitis, pneumonia, infective endocarditis, and autoimmune sequelae to streptococcal illnesses. Finally, the review addresses current and possible novel strategies to prevent superantigen production and passive and active immunization strategies.</jats:p>
収録刊行物
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- Clinical Microbiology Reviews
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Clinical Microbiology Reviews 26 (3), 422-447, 2013-07
American Society for Microbiology
