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- Vincent Mok
- From the Department of Medicine and Therapeutics (V.M., J.Y., A.W., K.S.W.), Department of Radiology & Organ Imaging (W.W.C.C., D.W., J.M.A.), The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China; Department of Neurology (D.D., J.F., Q.Z., Q.G., Z.H.), Huashan Hospital, Fudan University, Shanghai, China; Department of Neurology (Y.X.), Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu Province, China.
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- Ding Ding
- From the Department of Medicine and Therapeutics (V.M., J.Y., A.W., K.S.W.), Department of Radiology & Organ Imaging (W.W.C.C., D.W., J.M.A.), The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China; Department of Neurology (D.D., J.F., Q.Z., Q.G., Z.H.), Huashan Hospital, Fudan University, Shanghai, China; Department of Neurology (Y.X.), Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu Province, China.
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- Jianhui Fu
- From the Department of Medicine and Therapeutics (V.M., J.Y., A.W., K.S.W.), Department of Radiology & Organ Imaging (W.W.C.C., D.W., J.M.A.), The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China; Department of Neurology (D.D., J.F., Q.Z., Q.G., Z.H.), Huashan Hospital, Fudan University, Shanghai, China; Department of Neurology (Y.X.), Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu Province, China.
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- Yunyun Xiong
- From the Department of Medicine and Therapeutics (V.M., J.Y., A.W., K.S.W.), Department of Radiology & Organ Imaging (W.W.C.C., D.W., J.M.A.), The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China; Department of Neurology (D.D., J.F., Q.Z., Q.G., Z.H.), Huashan Hospital, Fudan University, Shanghai, China; Department of Neurology (Y.X.), Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu Province, China.
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- Winnie W.C. Chu
- From the Department of Medicine and Therapeutics (V.M., J.Y., A.W., K.S.W.), Department of Radiology & Organ Imaging (W.W.C.C., D.W., J.M.A.), The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China; Department of Neurology (D.D., J.F., Q.Z., Q.G., Z.H.), Huashan Hospital, Fudan University, Shanghai, China; Department of Neurology (Y.X.), Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu Province, China.
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- Defeng Wang
- From the Department of Medicine and Therapeutics (V.M., J.Y., A.W., K.S.W.), Department of Radiology & Organ Imaging (W.W.C.C., D.W., J.M.A.), The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China; Department of Neurology (D.D., J.F., Q.Z., Q.G., Z.H.), Huashan Hospital, Fudan University, Shanghai, China; Department of Neurology (Y.X.), Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu Province, China.
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- Jill M. Abrigo
- From the Department of Medicine and Therapeutics (V.M., J.Y., A.W., K.S.W.), Department of Radiology & Organ Imaging (W.W.C.C., D.W., J.M.A.), The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China; Department of Neurology (D.D., J.F., Q.Z., Q.G., Z.H.), Huashan Hospital, Fudan University, Shanghai, China; Department of Neurology (Y.X.), Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu Province, China.
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- Jie Yang
- From the Department of Medicine and Therapeutics (V.M., J.Y., A.W., K.S.W.), Department of Radiology & Organ Imaging (W.W.C.C., D.W., J.M.A.), The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China; Department of Neurology (D.D., J.F., Q.Z., Q.G., Z.H.), Huashan Hospital, Fudan University, Shanghai, China; Department of Neurology (Y.X.), Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu Province, China.
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- Adrian Wong
- From the Department of Medicine and Therapeutics (V.M., J.Y., A.W., K.S.W.), Department of Radiology & Organ Imaging (W.W.C.C., D.W., J.M.A.), The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China; Department of Neurology (D.D., J.F., Q.Z., Q.G., Z.H.), Huashan Hospital, Fudan University, Shanghai, China; Department of Neurology (Y.X.), Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu Province, China.
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- Qianhua Zhao
- From the Department of Medicine and Therapeutics (V.M., J.Y., A.W., K.S.W.), Department of Radiology & Organ Imaging (W.W.C.C., D.W., J.M.A.), The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China; Department of Neurology (D.D., J.F., Q.Z., Q.G., Z.H.), Huashan Hospital, Fudan University, Shanghai, China; Department of Neurology (Y.X.), Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu Province, China.
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- Qihao Guo
- From the Department of Medicine and Therapeutics (V.M., J.Y., A.W., K.S.W.), Department of Radiology & Organ Imaging (W.W.C.C., D.W., J.M.A.), The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China; Department of Neurology (D.D., J.F., Q.Z., Q.G., Z.H.), Huashan Hospital, Fudan University, Shanghai, China; Department of Neurology (Y.X.), Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu Province, China.
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- Zhen Hong
- From the Department of Medicine and Therapeutics (V.M., J.Y., A.W., K.S.W.), Department of Radiology & Organ Imaging (W.W.C.C., D.W., J.M.A.), The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China; Department of Neurology (D.D., J.F., Q.Z., Q.G., Z.H.), Huashan Hospital, Fudan University, Shanghai, China; Department of Neurology (Y.X.), Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu Province, China.
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- Ka Sing Wong
- From the Department of Medicine and Therapeutics (V.M., J.Y., A.W., K.S.W.), Department of Radiology & Organ Imaging (W.W.C.C., D.W., J.M.A.), The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, China; Department of Neurology (D.D., J.F., Q.Z., Q.G., Z.H.), Huashan Hospital, Fudan University, Shanghai, China; Department of Neurology (Y.X.), Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu Province, China.
書誌事項
- タイトル別名
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- A Community Study
- 公開日
- 2012-10
- DOI
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- 10.1161/strokeaha.112.665711
- 公開者
- Ovid Technologies (Wolters Kluwer Health)
この論文をさがす
説明
<jats:sec> <jats:title>Background and Purpose—</jats:title> <jats:p>We explored the association between pulsatility index (PI) as derived from transcranial Doppler ultrasound with various measures of small vessel disease in the community.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods—</jats:title> <jats:p>We performed transcranial Doppler and magnetic resonance imaging in 205 consecutive community-dwelling elderly subjects who were participants of the Shanghai Aging Study. We investigated the association between middle cerebral artery (MCA) PI with measures of white matter lesions (WML), lacunes, and microbleeds.</jats:p> </jats:sec> <jats:sec> <jats:title>Results—</jats:title> <jats:p> Multiple logistic regression found that MCA PI was associated with severe WML (odds ratio, 1.33 per 0.1 increase in PI; 95% confidence interval, 1.04–1.70; <jats:italic>P</jats:italic> =0.02). At optimal MCA PI cut-off, the area under curve, positive predictive value, and negative predictive value were 0.70 (95% confidence interval, 0.60–0.80), 34.9%, and 85.6%, respectively, for detection of severe WML. No association was found between MCA PI and measures of lacunes or microbleeds. </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p>PI correlates with WML severity. With a high negative predictive value, the chance of having severe WML with a normal PI is low. Transcranial Doppler may guide selective magnetic resonance imaging scanning for the detection of WML in the community.</jats:p> </jats:sec>
収録刊行物
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- Stroke
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Stroke 43 (10), 2791-2793, 2012-10
Ovid Technologies (Wolters Kluwer Health)