Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features
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- Rémi Buisson
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
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- Adam Langenbucher
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
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- Danae Bowen
- Department of Biological Chemistry, Center for Epigenetics and Metabolism, Chao Family Comprehensive Cancer Center, University of California, Irvine, CA, USA.
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- Eugene E. Kwan
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
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- Cyril H. Benes
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
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- Lee Zou
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
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- Michael S. Lawrence
- Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
書誌事項
- 公開日
- 2019-06-28
- DOI
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- 10.1126/science.aaw2872
- 公開者
- American Association for the Advancement of Science (AAAS)
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説明
<jats:title>APOBEC3A hairpin passenger hotspots</jats:title> <jats:p> Genomic features are often examined at extremes to determine the impact of mutations. These genomic regions span from the trinucleotide context to megabases that underlie chromatin and chromosomal features. Examining mutational dynamics at the mesoscale, the intermediate span of the genome, Buisson <jats:italic>et al.</jats:italic> characterized the mutational dynamics of cancer (see the Perspective by Carter). They found that mutations caused by the APOBEC enzyme in DNA stem-loops, a mesoscale feature of the genome, could drive recurrent mutations. Many of these types of mutations have been identified as likely drivers of cancer. However, APOBEC-generated mutations outside of stem-loops were more likely to be cancer driver mutations, providing a genomic context for separating cancer driver from passenger mutations. </jats:p> <jats:p> <jats:italic>Science</jats:italic> , this issue p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" related-article-type="in-this-issue" xlink:href="10.1126/science.aaw2872">eaaw2872</jats:related-article> ; see also p. <jats:related-article xmlns:xlink="http://www.w3.org/1999/xlink" ext-link-type="doi" issue="6447" page="1228" related-article-type="in-this-issue" vol="364" xlink:href="10.1126/science.aax9108">1228</jats:related-article> </jats:p>
収録刊行物
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- Science
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Science 364 (6447), eaaw2872-, 2019-06-28
American Association for the Advancement of Science (AAAS)