Comparative studies on the inhibition of liver amidases, aminopeptidase and serum cholinesterases by EPN

DOI Web Site Web Site PubMed 2 Citations

Description

Abstract The hydrolysis of isocarboxazid, a monoamine oxidase inhibitor, by rat liver homogenate was inhibited after treatment of rats with EPN at doses below those which inhibited serum cholinesterase. After single doses of EPN (5–15 mg/kg), almost complete inhibition of isocarboxazid amidase occurred sooner, and persisted longer, than cholinesterase inhibition. Tissue monoamine oxidase inhibition by isocarboxazid was reduced by pretreatment with EPN in rats. Administration of EPN for 3 consecutive days at lower doses (0.5–2.5 mg/kg) caused no inhibition of cholinesterase but produced a small, consistent, inhibition of liver isocarboxazid amidase. In this study the liver isocarboxazid amidase was shown to be a more sensitive indicator of exposure to EPN intoxication than serum cholinesterase inhibition.

Journal

Citations (2)*help

See more

Keywords

Report a problem

Back to top