A unique, predominant hepatitis C virus variant found in an infant born to a mother with multiple variants

DOI Web Site 被引用文献1件
  • A J Weiner
    Chiron Corporation, Emeryville, California 94608-2916.
  • M M Thaler
    Chiron Corporation, Emeryville, California 94608-2916.
  • K Crawford
    Chiron Corporation, Emeryville, California 94608-2916.
  • K Ching
    Chiron Corporation, Emeryville, California 94608-2916.
  • J Kansopon
    Chiron Corporation, Emeryville, California 94608-2916.
  • D Y Chien
    Chiron Corporation, Emeryville, California 94608-2916.
  • J E Hall
    Chiron Corporation, Emeryville, California 94608-2916.
  • F Hu
    Chiron Corporation, Emeryville, California 94608-2916.
  • M Houghton
    Chiron Corporation, Emeryville, California 94608-2916.

書誌事項

公開日
1993-07
権利情報
  • https://journals.asm.org/non-commercial-tdm-license
DOI
  • 10.1128/jvi.67.7.4365-4368.1993
公開者
American Society for Microbiology

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説明

<jats:p>To demonstrate vertical transmission of hepatitis C virus (HCV) from an HCV-infected, non-human immunodeficiency virus type 1-infected mother to her infant and to assess the distribution of viral species in the mother and infant, the hypervariable region of the gene encoding the putative envelope glycoprotein E2 (E2HV) was sequenced in three mothers and one mother-infant pair. The data indicate that (i) quasi-species distributions of HCV E2HV variants were found in all four mothers, (ii) a single predominant HCV E2HV variant was found in the infant of a mother shown to have nine predominant E2HV variants, and (iii) the infant's E2HV variant was highly related to, but not identical with, the nine variants identified in the mother at the time of birth. These findings indicate that HCV is transmitted from mother to infant and raise the possibility that the transmission occurs in utero.</jats:p>

収録刊行物

  • Journal of Virology

    Journal of Virology 67 (7), 4365-4368, 1993-07

    American Society for Microbiology

被引用文献 (1)*注記

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