PREGNANETRIOLONE EXCRETION IN STEIN-LEVENTHAL SYNDROME

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<jats:title>ABSTRACT</jats:title> <jats:p>Detectable amounts of pregnanetriolone were found in urines of 19 out of 20 women with clinical and histopathological evidence of the Stein-Leventhal syndrome.</jats:p> <jats:p>Twelve subjects were studied after ACTH, dexamethasone, and dexamethasone plus HCG administration.</jats:p> <jats:p>Pregnanetriolone excretion rose after ACTH infusion and fell after dexamethasone administration in all the patients.</jats:p> <jats:p>The combined administration of HCG and dexamethasone caused a significant increase in pregnanetriolone output in 8 out of 12 women.</jats:p> <jats:p>The combined administration of lynestrenol and mestranol in 4 HCG responsive patients, induced a decrease in pregnanetriolone excretion.</jats:p> <jats:p>After wedge resection, urinary pregnanetriolone was not detectable in 3 out of 7 patients.</jats:p> <jats:p>These data confirm the diagnostic importance of this compound in the evaluation of Stein-Leventhal syndrome and suggest the existence of two types of Stein-Leventhal syndrome (with respect to pregnanetriolone excretion) <jats:italic>i. e.</jats:italic> responsive and non responsive to HCG, and demonstrate that the ovary may be a source of 21-deoxycortisol.</jats:p>

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