Heritability Estimates Identify a Substantial Genetic Contribution to Risk and Outcome of Intracerebral Hemorrhage

DOI Web Site 被引用文献2件
  • William J. Devan
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Guido J. Falcone
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Christopher D. Anderson
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Jeremiasz M. Jagiella
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Helena Schmidt
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Björn M. Hansen
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Jordi Jimenez-Conde
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Eva Giralt-Steinhauer
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Elisa Cuadrado-Godia
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Carolina Soriano
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Alison M. Ayres
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Kristin Schwab
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Sylvia Baedorf Kassis
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Valerie Valant
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Joanna Pera
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Andrzej Urbanik
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Anand Viswanathan
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Natalia S. Rost
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Joshua N. Goldstein
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Paul Freudenberger
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Eva-Maria Stögerer
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Bo Norrving
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • David L. Tirschwell
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Magdy Selim
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Devin L. Brown
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Scott L. Silliman
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Bradford B. Worrall
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • James F. Meschia
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Chelsea S. Kidwell
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Joan Montaner
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Israel Fernandez-Cadenas
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Pilar Delgado
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Steven M. Greenberg
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Jaume Roquer
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Arne Lindgren
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Agnieszka Slowik
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Reinhold Schmidt
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Daniel Woo
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Jonathan Rosand
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...
  • Alessandro Biffi
    From the Center for Human Genetic Research (W.J.D., G.J.F., C.D.A., A.M.A., K.S., S.B.K., V.V., A.V., N.S.R., S.M.G., J.R., A.B.), Hemorrhagic Stroke Research Group (W.J.D., G.J.F., C.D.A., J.R., A.B.), Division of Neurocritical Care and Emergency Neurology, Department of Neurology (W.J.D., G.J.F., C.D.A., S.B.K., V.V., N.S.R., J.R., A.B.), and Department of Emergency Medicine (J.N.G.), Massachusetts General Hospital, Boston, MA;Program in Medical and Population Genetics, Broad Institute, Cambridge,...

抄録

<jats:sec> <jats:title>Background and Purpose—</jats:title> <jats:p>Previous studies suggest that genetic variation plays a substantial role in occurrence and evolution of intracerebral hemorrhage (ICH). Genetic contribution to disease can be determined by calculating heritability using family-based data, but such an approach is impractical for ICH because of lack of large pedigree-based studies. However, a novel analytic tool based on genome-wide data allows heritability estimation from unrelated subjects. We sought to apply this method to provide heritability estimates for ICH risk, severity, and outcome.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods—</jats:title> <jats:p> We analyzed genome-wide genotype data for 791 ICH cases and 876 controls, and determined heritability as the proportion of variation in phenotype attributable to captured genetic variants. Contribution to heritability was separately estimated for the <jats:italic>APOE</jats:italic> (encoding apolipoprotein E) gene, an established genetic risk factor, and for the rest of the genome. Analyzed phenotypes included ICH risk, admission hematoma volume, and 90-day mortality. </jats:p> </jats:sec> <jats:sec> <jats:title>Results—</jats:title> <jats:p> ICH risk heritability was estimated at 29% (SE, 11%) for non- <jats:italic>APOE</jats:italic> loci and at 15% (SE, 10%) for <jats:italic>APOE</jats:italic> . Heritability for 90-day ICH mortality was 41% for non- <jats:italic>APOE</jats:italic> loci and 10% (SE, 9%) for <jats:italic>APOE</jats:italic> . Genetic influence on hematoma volume was also substantial: admission volume heritability was estimated at 60% (SE, 70%) for non- <jats:italic>APOE</jats:italic> loci and at 12% (SE, 4%) for <jats:italic>APOE</jats:italic> . </jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions—</jats:title> <jats:p>Genetic variation plays a substantial role in ICH risk, outcome, and hematoma volume. Previously reported risk variants account for only a portion of inherited genetic influence on ICH pathophysiology, pointing to additional loci yet to be identified.</jats:p> </jats:sec>

収録刊行物

  • Stroke

    Stroke 44 (6), 1578-1583, 2013-06

    Ovid Technologies (Wolters Kluwer Health)

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