Asymmetric total synthesis of MK8383: the iron-mediated coupling reaction is the only effective method for the construction of the (Z)-trisubstituted side-chain alkene
書誌事項
- 公開日
- 2009-01
- 権利情報
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- https://www.elsevier.com/tdm/userlicense/1.0/
- DOI
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- 10.1016/j.tetlet.2008.10.138
- 公開者
- Elsevier BV
この論文をさがす
説明
Abstract The first asymmetric total synthesis of MK8383 through the iron-mediated coupling reaction is described. In this total synthesis, the key step was clearly the stereoselective construction of the ( Z )-trisubstituted side-chain alkene. Although this problem was seemingly easy to resolve, in fact it presented us an opportunity to evaluate the coupling reactions reported to date, and the iron-mediated coupling reaction was found to be the only effective method for the stereoselective construction of the ( Z )-trisubstituted side-chain alkene.
収録刊行物
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- Tetrahedron Letters
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Tetrahedron Letters 50 (2), 232-235, 2009-01
Elsevier BV