Epithelial Antibiotics Induced at Sites of Inflammation

Barry S. Schonwetter, Ethan D. Stolzenberg, Michael A. Zasloff

doi:10.1126/science.7886453

Epithelial Antibiotics Induced at Sites of Inflammation

DOI Web Site 被引用文献19件

Barry S. Schonwetter

Magainin Research Institute, Magainin Pharmaceuticals, Inc., Plymouth Meeting, PA 19462, USA.
Ethan D. Stolzenberg

Magainin Research Institute, Magainin Pharmaceuticals, Inc., Plymouth Meeting, PA 19462, USA.
Michael A. Zasloff

Magainin Research Institute, Magainin Pharmaceuticals, Inc., Plymouth Meeting, PA 19462, USA.

抄録

<jats:p>The role of antimicrobial peptides in epithelial defense is not fully understood. An epithelial β-defensin, lingual antimicrobial peptide (LAP), was isolated from bovine tongue and the corresponding complementary DNA cloned. LAP showed a broad spectrum of antibacterial and antifungal activities. LAP messenger RNA abundance was markedly increased in the epithelium surrounding naturally occurring tongue lesions. This increase coincided with the cellular hallmarks of acute and chronic inflammation in the underlying lamina propria, supporting a role for epithelial antimicrobial peptides as integral components of the inflammatory response.</jats:p>