Expression of <i>Pseudomonas aeruginosa</i> Virulence Genes Requires Cell-to-Cell Communication
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- Luciano Passador
- Department of Microbiology and Immunology, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14620.
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- James M. Cook
- Department of Microbiology and Immunology, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14620.
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- Michael J. Gambello
- Department of Microbiology and Immunology, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14620.
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- Lynn Rust
- Department of Microbiology and Immunology, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14620.
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- Barbara H. Iglewski
- Department of Microbiology and Immunology, University of Rochester, School of Medicine and Dentistry, Rochester, NY 14620.
説明
<jats:p> <jats:italic>Pseudomonas aeruginosa</jats:italic> is an opportunistic human pathogen that causes a variety of infections in immunocompromised hosts and individuals with cystic fibrosis. Expression of elastase, one of the virulence factors produced by this organism, requires the transcriptional activator LasR. Experiments with gene fusions show that gene <jats:italic>lasl</jats:italic> is essential for high expression of elastase. The <jats:italic>lasl</jats:italic> gene is involved in the synthesis of a diffusible molecule termed <jats:italic>Pseudomonas</jats:italic> autoinducer (PAI). PAI provides <jats:italic>P. aeruginosa</jats:italic> with a means of cell-to-cell communication that is required for the expression of virulence genes and may provide a target for therapeutic approaches. </jats:p>
収録刊行物
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- Science
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Science 260 (5111), 1127-1130, 1993-05-21
American Association for the Advancement of Science (AAAS)
