Intrastriatal Transplantation of Bone Marrow Nonhematopoietic Cells Improves Functional Recovery After Stroke in Adult Mice

DOI Web Site Web Site 被引用文献13件
  • Yi Li
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, U.S.A.
  • Michael Chopp
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, U.S.A.
  • Jieli Chen
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, U.S.A.
  • Lei Wang
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, U.S.A.
  • Subhash C. Gautam
    Division of Hematology/Oncology, Henry Ford Health Sciences Center, Detroit, Michigan, U.S.A.
  • Yong-Xian Xu
    Department of Physics, Oakland University, Rochester, Michigan, U.S.A.
  • Zhenggang Zhang
    Department of Neurology, Henry Ford Health Sciences Center, Detroit, Michigan, U.S.A.

書誌事項

公開日
2000-09
権利情報
  • https://journals.sagepub.com/page/policies/text-and-data-mining-license
DOI
  • 10.1097/00004647-200009000-00006
公開者
SAGE Publications

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<jats:p>The authors transplanted adult bone marrow nonhematopoietic cells into the striatum after embolic middle cerebral artery occlusion (MCAO). Mice (n = 23; C57BL/6J) were divided into four groups: (1) mice (n = 5) were subjected to MCAO and transplanted with bone marrow nonhematopoietic cells (prelabeled by bromodeoxyuridine, BrdU) into the ischemic striatum, (2) MCAO alone (n = 8), (3) MCAO with injection of phosphate buffered saline (n = 5), and (4) bone marrow nonhematopoietic cells injected into the normal striatum (n = 5). Mice were killed at 28 days after stroke. BrdU reactive cells survived and migrated a distance of approximately 2.2 mm from the grafting areas toward the ischemic areas. BrdU reactive cells expressed the neuronal specific protein NeuN in 1% of BrdU stained cells and the astrocytic specific protein glial fibrillary acidic protein (GFAP) in 8% of the BrdU stained cells. Functional recovery from a rotarod test ( P < 0.05) and modified neurologic severity score tests (including motor, sensory, and reflex; P < 0.05) were significantly improved in the mice receiving bone marrow nonhematopoietic cells compared with MCAO alone. The current findings suggest that the intrastriatal transplanted bone marrow nonhematopoietic cells survived in the ischemic brain and improved functional recovery of adult mice even though infarct volumes did not change significantly. Bone marrow nonhematopoietic cells may provide a new avenue to promote recovery of injured brain.</jats:p>

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