Emerging Biofabrication Strategies for Engineering Complex Tissue Constructs
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- R. Daniel Pedde
- Laboratory for Innovations in Microengineering (LiME) Department of Mechanical Engineering University of Victoria Victoria BC V8P 5C2 Canada
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- Bahram Mirani
- Laboratory for Innovations in Microengineering (LiME) Department of Mechanical Engineering University of Victoria Victoria BC V8P 5C2 Canada
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- Ali Navaei
- School of Biological and Health Systems Engineering (SBHSE) Arizona State University Tempe AZ 85281 USA
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- Tara Styan
- Willerth Laboratory, Department of Mechanical Engineering and Division of Medical Sciences University of Victoria Victoria V8P 5C2 Canada
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- Sarah Wong
- Willerth Laboratory, Department of Mechanical Engineering and Division of Medical Sciences University of Victoria Victoria V8P 5C2 Canada
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- Mehdi Mehrali
- Department of Micro‐ and Nanotechnology Center for Nanomedicine and Theranostics Technical University of Denmark Kgs. Lyngby 2800 Denmark
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- Ashish Thakur
- Department of Micro‐ and Nanotechnology Center for Nanomedicine and Theranostics Technical University of Denmark Kgs. Lyngby 2800 Denmark
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- Nima Khadem Mohtaram
- Laboratory for Innovations in Microengineering (LiME) Department of Mechanical Engineering University of Victoria Victoria BC V8P 5C2 Canada
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- Armin Bayati
- Willerth Laboratory, Department of Mechanical Engineering and Division of Medical Sciences University of Victoria Victoria V8P 5C2 Canada
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- Alireza Dolatshahi‐Pirouz
- Department of Micro‐ and Nanotechnology Center for Nanomedicine and Theranostics Technical University of Denmark Kgs. Lyngby 2800 Denmark
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- Mehdi Nikkhah
- School of Biological and Health Systems Engineering (SBHSE) Arizona State University Tempe AZ 85281 USA
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- Stephanie M. Willerth
- Willerth Laboratory, Department of Mechanical Engineering and Division of Medical Sciences University of Victoria Victoria V8P 5C2 Canada
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- Mohsen Akbari
- Laboratory for Innovations in Microengineering (LiME) Department of Mechanical Engineering University of Victoria Victoria BC V8P 5C2 Canada
抄録
<jats:p>The demand for organ transplantation and repair, coupled with a shortage of available donors, poses an urgent clinical need for the development of innovative treatment strategies for long‐term repair and regeneration of injured or diseased tissues and organs. Bioengineering organs, by growing patient‐derived cells in biomaterial scaffolds in the presence of pertinent physicochemical signals, provides a promising solution to meet this demand. However, recapitulating the structural and cytoarchitectural complexities of native tissues in vitro remains a significant challenge to be addressed. Through tremendous efforts over the past decade, several innovative biofabrication strategies have been developed to overcome these challenges. This review highlights recent work on emerging three‐dimensional bioprinting and textile techniques, compares the advantages and shortcomings of these approaches, outlines the use of common biomaterials and advanced hybrid scaffolds, and describes several design considerations including the structural, physical, biological, and economical parameters that are crucial for the fabrication of functional, complex, engineered tissues. Finally, the applications of these biofabrication strategies in neural, skin, connective, and muscle tissue engineering are explored.</jats:p>
収録刊行物
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- Advanced Materials
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Advanced Materials 29 (19), 2017-04-03
Wiley
