NEUROFIBROMATOSIS COMPLICATED BY INTRACRANIAL TUMORS

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<jats:p>Four cases of neurofibromatosis complicated by intracranial tumors are reported. Case 1 showed an intracranial neurofibromatosis while the other three cases contained gliomas in various stages of malignancy.</jats:p><jats:p>Japanese autopsy records for 11 years from 1958 to 1968 were investigated from a statistical point of view. Meningiomas and neurinomas associated with neurofibromatosis show an earlier peak of age distribution than that of those tumors without neurofibromatosis. There is no different age distribution between gliomas related to neurofibromatosis and the ones not related to it.</jats:p><jats:p>These facts suggest that both neurinomas and meningiomas associated with neurofibromatosis are intracranial manifestations of neurofibromatosis <jats:italic>perse</jats:italic>, while complicated gliomas are thought to be an incidental neoplasm, probably associated with transformation of disoriented neuroglial rests.</jats:p>

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