ERGIC-53 and traffic in the secretory pathway

DOI PDF 被引用文献20件
  • Hans-Peter Hauri
    University of Basel Department of Pharmacology, Biozentrum , , CH-4056 Basel Switzerland
  • Felix Kappeler
    University of Basel Department of Pharmacology, Biozentrum , , CH-4056 Basel Switzerland
  • Helena Andersson
    University of Basel Department of Pharmacology, Biozentrum , , CH-4056 Basel Switzerland
  • Christian Appenzeller
    University of Basel Department of Pharmacology, Biozentrum , , CH-4056 Basel Switzerland

書誌事項

公開日
2000-02-15
権利情報
  • http://www.biologists.com/user-licence-1-1/
DOI
  • 10.1242/jcs.113.4.587
公開者
The Company of Biologists

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説明

<jats:title>ABSTRACT</jats:title> <jats:p>The ER-Golgi intermediate compartment (ERGIC) marker ERGIC-53 is a mannose-specific membrane lectin operating as a cargo receptor for the transport of glycoproteins from the ER to the ERGIC. Lack of functional ERGIC-53 leads to a selective defect in secretion of glycoproteins in cultured cells and to hemophilia in humans. Beyond its interest as a transport receptor, ERGIC-53 is an attractive probe for studying numerous aspects of protein trafficking in the secretory pathway, including traffic routes, mechanisms of anterograde and retrograde traffic, retention of proteins in the ER, and the function of the ERGIC. Understanding these fundamental processes of cell biology will be crucial for the elucidation and treatment of many inherited and acquired diseases, such as cystic fibrosis, Alzheimer’s disease and viral infections.</jats:p>

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