Interleukin 4 induces cultured monocytes/macrophages to form giant multinucleated cells.

DOI PDF 被引用文献2件
  • A McInnes
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304.
  • D M Rennick
    Department of Immunology, DNAX Research Institute, Palo Alto, California 94304.

書誌事項

公開日
1988-02-01
DOI
  • 10.1084/jem.167.2.598
公開者
Rockefeller University Press

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説明

<jats:p>Giant multinucleated cells (GMCs) are associated with granulomatous lesions that form in response to various infectious and noninfectious agents. The present study shows that mouse IL-4 induces the in vitro formation of GMCs by factor-dependent bone marrow and alveolar monocytes via cell fusion. GMCs appear 2 d after incubation of cell cultures with 20 U/ml or more of IL-4. Anti-IL-4 mAbs block the appearance of GMCs in these cultures, indicating that IL-4 acts directly on monocytes to promote fusion and does not secondarily induce the production of other soluble fusion factors. In soft agar cultures, IL-4 also causes the aggregation of macrophages and diminishes their migration. The role of IL-4 in a granulomatous inflammatory response is discussed.</jats:p>

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