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- Amanda J Lee
- The Wolfson Unit for Prevention of Peripheral Vascular Diseases, Department of Public Health Sciences, University of Edinburgh, Edinburgh
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- F Gerald R Fowkes
- The Wolfson Unit for Prevention of Peripheral Vascular Diseases, Department of Public Health Sciences, University of Edinburgh, Edinburgh
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- Gordon D O Lowe
- The Haemostasis, Thrombosis and Vascular Medicine Unit, University Department of Medicine, Glasgow Royal Infirmary, Glasgow, UK
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- Ann Rumley
- The Haemostasis, Thrombosis and Vascular Medicine Unit, University Department of Medicine, Glasgow Royal Infirmary, Glasgow, UK
説明
<jats:title>Summary</jats:title><jats:p>Several haemostatic factors have been shown to have a predictive role in cardiovascular disease, although their relationship with prevalent peripheral arterial disease is not well reported. Using a random sample of 1592 men and women aged 55-74 years from Edinburgh, Scotland, we examined the relationship of von Willebrand factor (vWF), tissue plasminogen activator (t-PA) and fibrin D-dimer antigens and factor VII activity to peripheral arterial disease. t-PA antigen and fibrin D-dimer showed significant linear trends of increased levels with increasing severity of disease in both sexes (p ≤0.01) and vWF showed a similar pattern in men only (p ≤0.01). On multivariate analysis, fibrin D-dimer was independently related to the risk of intermittent claudication (p ≤0.01) and, among men, to the extent of arterial narrowing in the lower limb, as measured by the ankle brachial pressure index, (ABPI) (p ≤0.001). These results are further evidence of a role for intravascular fibrin deposition in the development of peripheral atherosclerosis.</jats:p>
収録刊行物
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- Thrombosis and Haemostasis
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Thrombosis and Haemostasis 74 (03), 828-832, 1995
Georg Thieme Verlag KG
