Massive and destructive T cell response to homeostatic cue in CD24-deficient lymphopenic hosts

Ou Li, Xing Chang, Huiming Zhang, Ergun Kocak, Cheng Ding, Pan Zheng, Yang Liu

doi:10.1084/jem.20052293

<jats:p>In response to a lymphopenic cue, T lymphocytes undergo a slow-paced homeostatic proliferation in an attempt to restore T cell cellularity. The molecular interaction that maintains the pace of homeostatic proliferation is unknown. In this study, we report that in lymphopenic CD24-deficient mice, T cells launch a massive proliferation that results in the rapid death of the recipient mice. The dividing T cells have phenotypes similar to those activated by cognate antigens. The rapid homeostatic proliferation is caused by a lack of CD24 on dendritic cells (DCs). Interestingly, although CD24 expression in T cells is required for optimal homeostatic proliferation in the wild-type (WT) host, mice lacking CD24 on all cell types still mount higher homeostatic proliferation than the WT mice. Thus, a lack of CD24 in the non–T host cells bypassed the requirement for T cell expression of CD24 in homeostatic proliferation in the WT host. Our data demonstrate that CD24 expressed on the DCs limits T cell response to homeostatic cue and prevents fatal damage associated with uncontrolled homeostatic proliferation.</jats:p>

Massive and destructive T cell response to homeostatic cue in CD24-deficient lymphopenic hosts

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Massive and destructive T cell response to homeostatic cue in CD24-deficient lymphopenic hosts

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収録刊行物

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