Relaxation Enhancement of the Dog Liver and Spleen by Biodegradable Superparamagnetic Particles in Proton Magnetic Resonance Imaging
書誌事項
- 公開日
- 1987-11
- 権利情報
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- http://journals.sagepub.com/page/policies/text-and-data-mining-license
- DOI
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- 10.1177/028418518702800608
- 公開者
- SAGE Publications
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説明
<jats:p> Bio-degradable superparamagnetic particles of about 0.5 μm diameter were investigated in 2 dogs as potential intravenous contrast enhancing agents for the reticuloendothelial system. The particles lowered the MRI signal of the liver for all investigated sequences, while the signal of the spleen was lowered only in T2 weighted sequences. No clear effect was seen on signals of fat and muscle. There was a pronounced effect on T 2 in both liver and spleen but relatively little effect on T1. Diminishing contrast effect with time indicates that the particles degrade. The particles did not have any adverse effects on the general state of the dogs or on routine liver and kidney function tests. </jats:p>
収録刊行物
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- Acta Radiologica
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Acta Radiologica 28 (6), 703-705, 1987-11
SAGE Publications