mTOR inhibition and adult T-cell leukemia

説明

Human T-cell leukemia virus type I (HTLV-I) is ahuman retrovirus and an aetiologic agent of adult T-cell leukemia/lymphoma (ATL/ATLL) [1,2]. ATL/ATLL have a poor prognosis with a median survivalrate of *6 months [3]. Novel therapeutic strategiesfor ATL are required. In the current study, wefocused on mammalian target of rapamycin (mTOR)[4], a serine/threonine kinase that is a downstream

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