Notch signaling regulates the differentiation of post-mitotic intestinal epithelial cells

DOI Web Site 被引用文献2件

説明

<jats:p>The intestinal epithelium comprises differentiated cells of four lineages maintained by precursor cells. As the Notch pathway controls the fate of proliferating cells in many systems, we investigated the effect of conditional expression of an activated Notch mutant in intestinal epithelium. An increase in the number of goblet cells occurs within 8 h of induction, due to an effect of Notch on post-mitotic cells, not on precursors. This observation broadens the role of Notch into controlling postmitotic differentiation and indicates that the composition of the epithelium is not solely determined by progenitor cells.</jats:p>

収録刊行物

  • Genes & Development

    Genes & Development 19 (14), 1686-1691, 2005-07-15

    Cold Spring Harbor Laboratory

被引用文献 (2)*注記

もっと見る

詳細情報 詳細情報について

問題の指摘

ページトップへ