Leptin action in normal and pathological pregnancies

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  • Antonio Pérez‐Pérez
    Department of Medical Biochemistry and Molecular Biology Virgen Macarena University Hospital University of Seville Seville Spain
  • Ayelén Toro
    Laboratory of Placental Molecular Physiology Department of Biological Chemistry School of Sciences University of Buenos Aires IQUIBICEN‐CONICET Buenos Aires Argentina
  • Teresa Vilariño‐García
    Department of Medical Biochemistry and Molecular Biology Virgen Macarena University Hospital University of Seville Seville Spain
  • Julieta Maymó
    Laboratory of Placental Molecular Physiology Department of Biological Chemistry School of Sciences University of Buenos Aires IQUIBICEN‐CONICET Buenos Aires Argentina
  • Pilar Guadix
    Department of Obstetrics and Gynecology Virgen Macarena University Hospital University of Seville Seville Spain
  • José L. Dueñas
    Department of Obstetrics and Gynecology Virgen Macarena University Hospital University of Seville Seville Spain
  • Manuel Fernández‐Sánchez
    Valencian Infertility Institute (IVI) Seville Spain
  • Cecilia Varone
    Laboratory of Placental Molecular Physiology Department of Biological Chemistry School of Sciences University of Buenos Aires IQUIBICEN‐CONICET Buenos Aires Argentina
  • Víctor Sánchez‐Margalet
    Department of Medical Biochemistry and Molecular Biology Virgen Macarena University Hospital University of Seville Seville Spain

書誌事項

公開日
2017-11-21
権利情報
  • http://creativecommons.org/licenses/by/4.0/
DOI
  • 10.1111/jcmm.13369
公開者
Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>Leptin is now considered an important signalling molecule of the reproductive system, as it regulates the production of gonadotrophins, the blastocyst formation and implantation, the normal placentation, as well as the foeto‐placental communication. Leptin is a peptide hormone secreted mainly by adipose tissue, and the placenta is the second leptin‐producing tissue in humans. Placental leptin is an important cytokine which regulates placental functions in an autocrine or paracrine manner. Leptin seems to play a crucial role during the first stages of pregnancy as it modulates critical processes such as proliferation, protein synthesis, invasion and apoptosis in placental cells. Furthermore, deregulation of leptin levels has been correlated with the pathogenesis of various disorders associated with reproduction and gestation, including polycystic ovary syndrome, recurrent miscarriage, gestational diabetes mellitus, pre‐eclampsia and intrauterine growth restriction. Due to the relevant incidence of the mentioned diseases and the importance of leptin, we decided to review the latest information available about leptin action in normal and pathological pregnancies to support the idea of leptin as an important factor and/or predictor of diverse disorders associated with reproduction and pregnancy.</jats:p>

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