Streptozotocin-Induced Pancreatic Insulitis: New Model of Diabetes Mellitus

DOI Web Site 被引用文献28件

書誌事項

公開日
1976-07-30
DOI
  • 10.1126/science.180605
公開者
American Association for the Advancement of Science (AAAS)

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説明

<jats:p>Multiple small injections of streptozotocin in mice produce pancreatic insulitis, with progression to nearly complete beta cell destruction and diabetes mellitus. The timing and appearance of the inflammatory islet lesions suggest but do not prove that streptozotocin acts by initiating a cell-mediated immune reaction. Ultrastructural evidence of abundant type C viruses within beta cells of treated mice suggests that streptozotocin may activate murine leukemia virus in vivo in susceptible hosts.</jats:p>

収録刊行物

  • Science

    Science 193 (4251), 415-417, 1976-07-30

    American Association for the Advancement of Science (AAAS)

被引用文献 (28)*注記

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