Tumour Necrosis Factor-α Polymorphisms and Hepatocellular Carcinoma: A Meta-analysis
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- H Qin
- Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China
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- B Liu
- Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China
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- T Shi
- Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China
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- Y Liu
- Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China
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- Y Sun
- Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China
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- Y Ma
- Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China
説明
<jats:p>The genetic basis of susceptibility to hepatocellular carcinoma (HCC) is poorly understood. To summarize the quantitative association between polymorphisms of the tumour necrosis factor-α ( TNFA) gene and HCC, a meta-analysis of relevant studies was performed. Ten case–control studies involving 1421 HCC cases were identified from the Medline®, Embase® and Current Contents® databases. Combined results based on all studies showed that patients with HCC had a significantly lower frequency of the TNFA gene polymorphism −308GG than healthy controls. When stratifying for race, results were similar among Asians and Caucasians. When comparing with hepatitis B virus infection cases, no statistical association was found. This meta-analysis suggests that TNFA −308GG gene polymorphism is associated with a modest decrease in the risk of HCC.</jats:p>
収録刊行物
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- Journal of International Medical Research
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Journal of International Medical Research 38 (3), 760-768, 2010-06
SAGE Publications