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- Hashem A. Dbouk
- Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; and
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- Chou-Long Huang
- Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas
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- Melanie H. Cobb
- Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas; and
書誌事項
- 公開日
- 2016-07-01
- DOI
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- 10.1152/ajprenal.00358.2015
- 公開者
- American Physiological Society
この論文をさがす
説明
<jats:p> The With no Lysine [K] (WNK) family of enzymes are central in the regulation of blood pressure. WNKs have been implicated in hereditary hypertension disorders, mainly through control of the activity and levels of ion cotransporters and channels. Actions of WNKs in the kidney have been heavily investigated, and recent studies have provided insight into not only the regulation of these enzymes but also how mutations in WNKs and their interacting partners contribute to hypertensive disorders. Defining the roles of WNKs in the cardiovascular system will provide clues about additional mechanisms by which WNKs can regulate blood pressure. This review summarizes recent developments in the regulation of the WNK signaling cascade and its role in regulation of blood pressure. </jats:p>
収録刊行物
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- American Journal of Physiology-Renal Physiology
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American Journal of Physiology-Renal Physiology 311 (1), F16-F27, 2016-07-01
American Physiological Society