Efficient synthesis of tetrahydronaphthalene- or isochroman-fused spirooxindoles using tandem reactions
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- Biao Wang
- State Key Laboratory Breeding Base of Systematic Research
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- Hai-Jun Leng
- Ministry of Education Key Laboratory of Standardization of Chinese Medicine
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- Xue-Yuan Yang
- State Key Laboratory Breeding Base of Systematic Research
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- Bo Han
- State Key Laboratory Breeding Base of Systematic Research
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- Chao-Long Rao
- Ministry of Education Key Laboratory of Standardization of Chinese Medicine
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- Li Liu
- Ministry of Education Key Laboratory of Standardization of Chinese Medicine
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- Cheng Peng
- State Key Laboratory Breeding Base of Systematic Research
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- Wei Huang
- State Key Laboratory Breeding Base of Systematic Research
説明
<p>The cascade reaction involving a Michael–aldol or vinylogous Henry-acetalization relay is described. We have used the cascade reaction to assemble tetrahydronaphthalene- or isochroman-fused spirooxindoles and other drug-like spirocyclic scaffolds.</p>
収録刊行物
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- RSC Advances
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RSC Advances 5 (107), 88272-88276, 2015
Royal Society of Chemistry (RSC)
