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- Matthew Fogarty
- The Wolfson Institute for Biomedical Research and Department of Biology,University College London (UCL), Gower Street, London WC1E 6BT, UK
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- William D. Richardson
- The Wolfson Institute for Biomedical Research and Department of Biology,University College London (UCL), Gower Street, London WC1E 6BT, UK
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- Nicoletta Kessaris
- The Wolfson Institute for Biomedical Research and Department of Biology,University College London (UCL), Gower Street, London WC1E 6BT, UK
書誌事項
- 公開日
- 2005-04-15
- DOI
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- 10.1242/dev.01777
- 公開者
- The Company of Biologists
この論文をさがす
説明
<jats:p>Many oligodendrocytes in the spinal cord are derived from a region of the ventral ventricular zone (VZ) that also gives rise to motoneurons. Cell fate specification in this region depends on sonic hedgehog (Shh) from the notochord and floor plate. There have been suggestions of an additional source(s) of oligodendrocytes in the dorsal spinal cord. We revisited this idea by Cre-lox fate-mapping in transgenic mice. We found that a subpopulation of oligodendrocytes is generated from the Dbx1-expressing domain of the VZ,spanning the dorsoventral midline. Dbx-derived oligodendrocytes comprise less than 5% of the total; they are formed late during embryogenesis by transformation of radial glia and settle mainly in the lateral white matter. Development of Dbx-derived oligodendrocytes in vitro can occur independently of Shh but requires FGF signalling. Dbx-expressing precursors also generate astrocytes and interneurons, but do not contribute to the ependymal layer of the postnatal spinal cord.</jats:p>
収録刊行物
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- Development
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Development 132 (8), 1951-1959, 2005-04-15
The Company of Biologists