Effect of Different Classes of Antihypertensive Drugs on Endothelial Function and Inflammation
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- Isabella Viana Gomes Silva
- Campus Centro Oeste Dona Lindu—Universidade Federal de São João del-Rei, Chanadour 400, Brazil
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- Roberta Carvalho de Figueiredo
- Campus Centro Oeste Dona Lindu—Universidade Federal de São João del-Rei, Chanadour 400, Brazil
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- Danyelle Romana Alves Rios
- Campus Centro Oeste Dona Lindu—Universidade Federal de São João del-Rei, Chanadour 400, Brazil
説明
<jats:p>Hypertension is characterized by structural and functional changes in blood vessels that travel with increased arterial stiffness, vascular inflammation, and endothelial dysfunction. Some antihypertensive drugs have been shown to improve endothelial function and reduce levels of inflammatory markers regardless of the effect of blood pressure lowering. Third-generation β-blockers, such as nebivolol and carvedilol, because they have additional properties, have been shown to improve endothelial function in patients with hypertension. Calcium channel antagonists, because they have antioxidant effects, may improve endothelial function and vascular inflammation.The Angiotensin Receptor Blocker (ARBs) are able to improve endothelial dysfunction and vascular inflammation in patients with hypertension and other cardiovascular diseases. Angiotensin converting enzyme (ACE) inhibitors have shown beneficial effects on endothelial function in patients with hypertension and other cardiovascular diseases, however there are few studies evaluating the effect of treatment with this class on the reduction of C-reactive protein (CRP) levels. Further studies are needed to assess whether treatment of endothelial dysfunction and vascular inflammation may improve the prognosis of patients with essential hypertension.</jats:p>
収録刊行物
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- International Journal of Molecular Sciences
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International Journal of Molecular Sciences 20 (14), 3458-, 2019-07-14
MDPI AG