An Artificial Imine Reductase based on the Ribonuclease S Scaffold

Maika Genz, Valentin Köhler, Michel Krauss, David Singer, Ralf Hoffmann, Thomas R. Ward, Norbert Sträter

doi:10.1002/cctc.201300995

An Artificial Imine Reductase based on the Ribonuclease S Scaffold

DOI Web Site Web Site 被引用文献2件

書誌事項

公開日: 2014-02-03

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http://onlinelibrary.wiley.com/termsAndConditions#vor

DOI

10.1002/cctc.201300995

公開者: Wiley

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説明

<jats:title>Abstract</jats:title><jats:p>Dative anchoring of a piano‐stool complex within ribonuclease S resulted in an artificial imine reductase. The catalytic performance was modulated upon variation of the coordinating amino acid residues in the S‐peptide. Binding of Cp*Ir (Cp*=C<jats:sub>5</jats:sub>Me<jats:sub>5</jats:sub>) to the native active site resulted in good conversions and moderate enantiomeric excess values for the synthesis of salsolidine.</jats:p>