Membrane Tethering and Fusion in the Secretory and Endocytic Pathways

DOI Web Site Web Site 1 Citations

Search this article

Description

<jats:p>Studies of intracellular trafficking over the past decade or so have led to striking advances in our understanding of the molecular processes by which transport intermediates dock and fuse. SNARE proteins play a central role, assembling into complexes that bridge membranes and may catalyze membrane fusion directly. In general, different SNARE proteins operate in different intracellular trafficking pathways, so recent reports that SNARE assembly <jats:italic>in vitro</jats:italic> is promiscuous have come as something of a surprise. We propose a model in which proper SNARE assembly is under kinetic control, orchestrated by members of the Sec1 protein family, small GTP‐binding Rab proteins, and a diverse assortment of tethering proteins.</jats:p>

Journal

  • Traffic

    Traffic 1 (8), 588-597, 2000-08

    Wiley

Citations (1)*help

See more

Report a problem

Back to top